BioProcess360: Integrated Upstream and Downstream Bioprocessing
FLEXBIO, Heriot-Watt University, Edinburgh
4 - 8 May 2026
£2600
This 5-day comprehensive training course offers an end-to-end exploration of the biomanufacturing process, integrating both upstream and downstream operations into a unified, hands-on learning experience. Participants will begin by cultivating a recombinant protein using a microbial expression system in a 30 L stainless steel stirred-tank bioreactor, gaining direct experience in bioreactor setup, sterilisation, inoculation, monitoring, and harvest procedures.
The course then transitions to downstream processing, where participants will apply industryrelevant techniques including disc-stack centrifugation, high-pressure homogenisation, tangential flow filtration (TFF), and chromatography to recover and purify the expressed protein.
With a balanced focus on theoretical grounding and practical application, this course is ideal for professionals seeking a complete understanding of the bioprocessing workflow - from cell culture through to purified product. A certificate of completion will be awarded upon successful participation.
Learning outcomes:
Gain hands-on experience in upstream processing by cultivating recombinant protein in a 30 L bioreactor, focusing on preparation, sterilisation, inoculation, and real-time monitoring.
Understand the full bioprocessing workflow, connecting upstream operations with downstream purification strategies.
Apply key downstream techniques including centrifugation, homogenisation, TFF, and chromatography to isolate and purify the target protein.
Develop skills to monitor, troubleshoot, and optimise process parameters at every stage for improved yield and product quality.
Who should attend?
Scientists, engineers, graduates, and technical professionals interested in gaining a holistic view of biomanufacturing.
Individuals seeking to build or strengthen practical skills across both upstream and downstream bioprocessing workflows.